01 - In a small bowl, combine salt, black pepper, paprika, garlic powder, and onion powder until evenly incorporated.
02 - Sprinkle both sides of each tilapia fillet evenly with the seasoning mixture, pressing gently so the spices adhere.
03 - For extra crispiness, lightly dredge the seasoned fillets in cornmeal or gluten-free flour, shaking off any excess.
04 - Heat olive oil or butter in a large nonstick skillet over medium-high heat until the fat shimmers and just begins to smoke lightly.
05 - Carefully place the fillets in the hot skillet, working in batches if necessary to avoid crowding. Cook for 3–4 minutes on the first side until golden and the fish releases easily from the pan.
06 - Flip the fillets gently using a fish spatula and cook for another 2–3 minutes until the flesh is completely opaque and flakes easily with a fork.
07 - Transfer to plates immediately and serve with fresh lemon wedges alongside steamed vegetables, a salad, or rice.